Venous Leg Ulcers

Protease-modulating matrix treatments for healing venous leg ulcers

First-line treatment for VLUs is compression therapy, but around 60% of people have unhealed ulcers after 12 weeks’ treatment and about 40% after 24 weeks; therefore, there is scope for further improvement. Limited evidence suggests non-healing leg ulcers may have persisting elevated levels of proteases, which is thought to deter the later stages of healing; thus, timely protease-modulating matrix (PMM) treatments may improve healing by physically removing proteases from the wound fluid.

Source: Protease-modulating matrix treatments for healing venous leg ulcers